Inhibition of B Virus in Cell Culture by 5-Iodo-2′-Deoxyuridine
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چکیده
منابع مشابه
Treatment of Non-gonococcal Urethritis with 5-iodo-2'-deoxyuridine.
5-iodo-2'-deoxyuridine (5IDU) is an antiviral compound which has a chemical composition closely resembling that of thymidine; the antiviral effect is thought to be due to the metabolic antagonism to the uptake of thymidine in the deoxyribonucleic acid (DNA) molecule (Prusoff, 1959). This molecule combined with protein is the main composition of the herpes simplex virus, upon the metabolism of w...
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There is a concern that there may be unregistered stocks of smallpox that can be used for bioterrorism or biological warfare. According to the WHO Advisory Committee on Variola Research, there is a need to develop strategies to treat smallpox infections should they reappear. It would also be important to have an effective drug at hand for the treatment of monkeypox disease in humans. We show he...
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THE results of treating herpetic keratitis with the antiviral agent 5-iodo-2'deoxyuridine have proved, after initial enthusiasm, to be somewhat variable. In most instances the number of cases analysed has been small (Bennett, 1962; Corrigan, Gilkes, and Roberts, 1962; Davidson, 1962; Kaufman and Maloney, 1962; Luntz and MacCallum, 1963). More accurate conclusions can best be reached by a double...
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uridine (lUdR) there was an increase in alkaline phosphatase activity after about 24 hr, reaching a maximum usually at about 72 hi. At this concentration, during this time, there was a relatively small inhibition of cell replication. The increment in alkaline phosphatase activity was in large measure prevented by concomitant addition of 10 /¿Mthymidine. Further, lUdR did not increase alkaline ...
متن کاملAdrenal corticosteroids enhance production of type-C virus induced by 5-iodo-2'-deoxyuridine from cultured mouse fibroblasts.
Induction of RNA "tumor" viruses by 5-iodo-2'-deoxyuridine in mouse fibroblasts is stimulated 5- to 25-fold by glucogenic adrenal corticosteroids. Enhancement of virus production by the hormones is inhibited by low concentration of cordycepin, an inhibitor of poly(A) synthesis.
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ژورنال
عنوان ژورنال: Applied Microbiology
سال: 1967
ISSN: 0003-6919
DOI: 10.1128/am.15.4.733-735.1967